In this systematic literature review and meta-analysis, researchers evaluated the relationship between dietary intake of lutein and zeaxanthin and age-related macular degeneration (AMD) risk. The results showed dietary intake of lutein and zeaxanthin was significantly related with a reduction in risk of late AMD and a statistically significant inverse association between these carotenoids and neovascular AMD risk. No significant relationship was found for lutein and zeaxanthin intake and early AMD.
Ma L, Dou HL, Wu YQ, Huang YM, Huang YB, Xu XR, Zou ZY, Lin XM. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr. 2012 Feb;107(3):350-9.